f(x) columns for mechanistic modeling of chromatography

f(x) prepacked and precharacterized chromatography columns give you faster and more reliable mechanistic modeling during downstream process development.

Precharacterized column — supplied with a Results of Analysis that provides you with column-specific data for use in mechanistic modeling workflow. Ensures accurate model parameter values and reduces the time you need for column characterization.
High-quality prepacked columns — packed with high-productivity BioProcess™ resin by Cytiva experts.
Lab-scale process development column format — resin packed in Tricorn™ 10/200 or 10/100 columns, which are tailored for experiments during process development and for process characterization.

f(x) columns for faster and more reliable mechanistic modeling results

To determine column parameters required for the model, you need to perform column characterization experiments. This takes time and requires expert knowledge to ensure that accurate parameter values are produced. With f(x) columns, your parameter values are instantly available, accurate, and include:

	Parameters included in the Results of Analysis for the following f(x) columns
	Ion exchange and multimodal chromatography	Hydrophobic interaction chromatography
Bed height (cm)	Yes	Yes
Total porosity	Yes	Yes
Interstitial porosity	Yes	Yes
Ionic capacity (μmol/mL), column specific and in resin backbone	Yes	N/A
Bed volume (mL)	Yes	Yes
Bead radius (µm)	Yes	Yes
Total specific adsorber surface area (m^-1)	Yes	Yes
Specific adsorber surface area (m^-1)	Yes	Yes
Ligand density (µmol/m²)	Yes	N/A
Ligand pK_a	Yes	N/A
Axial dispersion (mm²/s)	Yes	Yes

f(x) columns give you confidence about the column parameters used for your model (including colloidal particle adsorption (CPA) model), and free up your time to focus on generating molecule-specific data. They are a good complement to GoSilico™ Chromatography Modeling Software.

A suitable column format for your process development work

Tricorn™ columns are high-quality, prepacked columns for robust and reproducible process development and validation. Because of the narrow 10 mm inner diameter combined with 20 cm or 10 cm bed height typically used in biomanufacturing, these columns are especially suited to scale-down studies.

About mechanistic modeling in chromatography

Mechanistic models use computer simulations to decrease the number of experiments needed during process development, and increase the design space investigated. These simulations are based on known physiochemical phenomena involved in chromatography and offer you the following advantages:

Cost reduction and time saving — more data obtained from fewer experiments, which accelerates your process development.
Improved robustness and efficiency to fulfill regulatory demands on quality by design.

Learn more about mechanistic modeling.

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Product	Product Name	Chromatography technique All Multimodal Anion exchange Cation exchange Hydrophobic interaction	Dimensions All 10 × 100 mm 10 × 200 mm	Pack size All 1	Price
29716743	Capto™ S ImpAct Tricorn™ 10/200 f(x) Item must be purchased in units of 1	Cation exchange	10 × 200 mm	1	On Request
29723328	Capto™ MMC ImpRes Tricorn™ 10/100 f(x) Item must be purchased in units of 1	Multimodal	10 × 100 mm	1	On Request
29723332	Capto™ Q ImpRes Tricorn™ 10/100 f(x) Item must be purchased in units of 1	Anion exchange	10 × 100 mm	1	On Request
29723450	Capto™ adhere ImpRes Tricorn™ 10/200 f(x) Item must be purchased in units of 1	Multimodal	10 × 200 mm	1	On Request
29716744	Capto™ SP ImpRes Tricorn™ 10/100 f(x) Item must be purchased in units of 1	Cation exchange	10 × 100 mm	1	On Request
29722931	Capto™ MMC ImpRes Tricorn™ 10/200 f(x) Item must be purchased in units of 1	Multimodal	10 × 200 mm	1	On Request
29723451	Capto™ Q ImpRes Tricorn™ 10/200 f(x) Item must be purchased in units of 1	Anion exchange	10 × 200 mm	1	On Request
29716581	Capto™ S ImpAct Tricorn™ 10/100 f(x) Item must be purchased in units of 1	Cation exchange	10 × 100 mm	1	On Request
29723329	Capto™ adhere ImpRes Tricorn™ 10/100 f(x) Item must be purchased in units of 1	Multimodal	10 × 100 mm	1	On Request
29745845	Capto™ Butyl Tricorn™ 10/100 f(x) Item must be purchased in units of 1	Hydrophobic interaction	10 × 100 mm	1	On Request
29745844	Capto™ Butyl Tricorn™ 10/200 f(x) Item must be purchased in units of 1	Hydrophobic interaction	10 × 200 mm	1	On Request
29745842	Capto™ Butyl ImpResTricorn™ 10/200 f(x) Item must be purchased in units of 1	Hydrophobic interaction	10 × 200 mm	1	On Request
29745849	Capto™ Phenyl (High Sub) Tricorn™ 10/100 f(x) Item must be purchased in units of 1	Hydrophobic interaction	10 × 100 mm	1	On Request
29745848	Capto™ Phenyl (High Sub) Tricorn™ 10/200 f(x) Item must be purchased in units of 1	Hydrophobic interaction	10 × 200 mm	1	On Request
29745847	Capto™ Phenyl ImpRes Tricorn™ 10/100 f(x) Item must be purchased in units of 1	Hydrophobic interaction	10 × 100 mm	1	On Request
29745846	Capto™ Phenyl ImpRes Tricorn™ 10/200 f(x) Item must be purchased in units of 1	Hydrophobic interaction	10 × 200 mm	1	On Request
29745843	Capto™ Butyl ImpRes Tricorn™ 10/100 f(x) Item must be purchased in units of 1	Hydrophobic interaction	10 × 100 mm	1	On Request
29728243	Capto™ adhere Tricorn™ 10/100 f(x) Item must be purchased in units of 1	Multimodal	10 × 100 mm	1	On Request
29728468	Capto™ Q Tricorn™ 10/200 f(x) Item must be purchased in units of 1	Anion exchange	10 × 200 mm	1	On Request
29728470	Capto™ Q Tricorn™ 10/100 f(x) Item must be purchased in units of 1	Anion exchange	10 × 100 mm	1	On Request
29728113	Capto™ adhere Tricorn™ 10/200 f(x) Item must be purchased in units of 1	Multimodal	10 × 200 mm	1	On Request
29728144	Capto™ MMC Tricorn™ 10/200 f(x) Item must be purchased in units of 1	Multimodal	10 × 200 mm	1	On Request
29728467	Capto™ MMC Tricorn™ 10/100 f(x) Item must be purchased in units of 1	Multimodal	10 × 100 mm	1	On Request
29641492	Capto™ SP ImpRes Tricorn™ 10/200 f(x) Item must be purchased in units of 1	Cation exchange	10 × 200 mm	1	On Request

f(x) columns for mechanistic modeling of chromatography

f(x) columns for mechanistic modeling of chromatography

f(x) columns for faster and more reliable mechanistic modeling results

A suitable column format for your process development work

About mechanistic modeling in chromatography

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