The following parameters should be considered at a minimum:

• Throughput and flux
• Transmission of active ingredients and excipients
• Extractables and leachables
• Material compatibility
• Filter format (single-use vs stainless steel) and filter sizing
• Integrity test procedures

Please contact us for more information.

Supor™ Prime filters are specifically designed for critical, high concentration, high viscosity applications. A filterability study should be performed to determine if Supor™ Prime is the right membrane for your process fluid. Please contact us to perform a trial on your process.

Supor™ Prime filters can be used in any process step in which a sterile effluent is produced. Evaluation under process conditions is strongly recommended to determine the most appropriate filter in the Cytiva range. Please contact us to perform a trial on your process.

Formulations can sometimes be made at low concentration in early clinical phases and then increased to a high concentration at a later phase. If an increase in concentration is possible for your drug development, consider Supor™ Prime filters to avoid extensive re-evaluation. Please contact us for more information.

Supor™ Prime filters are designed for use in challenging feeds. In mAb applications, the throughput is twice that of competitor filters. See full details in this Application Note. Please contact us to perform a trial on your process.

Supor™ Prime filters are designed to minimize the adsorption of excipients such as polysorbate 20 and polysorbate 80. Please contact us to perform a trial on your process.

Low extractables are critical in final filtration and Supor™ Prime filters are designed to address this concern. Please reference the extractables table in the Supor™ Prime datafile. Compound specific extractables are available from the regulatory portal. Please contact us for more information

The increased performance of Supor™ Prime filters allows for a reduction in filter size which means less product lost to non-recoverable volume. Please contact us for more information.

The maximum operating pressure is 6.5 barg (94 psig) at 60°C for 24 hours (large capsule) of continuous service. This gives high confidence during product wet integrity test or blowdown. The high pressure rating of this capsule allows viscous fluids to be filtered at higher pressures. Please contact us to perform a trial on your process.