The working volumes and turn-down ratios of the bioreactors are:

XDR biocontainers are constructed with a contact layer of USP class VI-compliant low-density polyethylene (LDPE) plastic and are robust to withstand process conditions. All bioreactor bag assemblies incorporate a seal-less, bottom-mounted, impeller/sparger assembly with a centrally positioned integral magnet.

Xcellerex™ XDR bioreactors can be used for batch, fed-batch, and perfusion processes. They have been used to successfully grow a wide range of cell types and organisms including CHO, Vero, HECK293, and MDCK cells. They are also proven for use in multiple applications including mAbs, viral vectors, and vaccines.

Although the space required for each bioreactor varies with their size, the site requirements are similar for all vessel sizes. Consult the site preparation guide for details and a checklist.

Traditional scaling methodology, based on measures such as shear, tip speed, power per unit volume, kLa, and specific process sensitivities, can be used during scale-up. Technology transfer using the Xcellerex™ XDR systems is straightforward, minimizing the need for costly and time-consuming process redesign. The Cytiva Bioreactor Scaler tool is available to help you achieve seamless scaling from process development to biomanufacturing scale. This digital tool predicts operating parameters based on scaling parameters as well as bioreactor and cell line characteristics. The result is a more efficiently established and verified bioreactor scaling process for your Xcellerex™ XDR bioreactor.