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静脉输液颗粒截留

在静脉输液期间,在线过滤器可阻止数百万意外颗粒注入患者体内

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IV 颗粒污染

静脉输液溶液有许多污染源,包括药物混合不完全、药物不相容性反应、肠外营养成分的聚集、容器或安瓿的玻璃、塑料或输液系统的组件。

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  2. Langille SE. Particulate Matter in Injectable Drug Products. PDA J Pharm Sci Tech. 2013;67:186-200.
  3. Ilium L, Davis SS, Wilson CG, Thomas NW, Frier M, Hardy JG. Blood clearance and organ deposition of intravenously administered colloidal particles. The effects of particle size, nature and shape. Int J Pharm. 1982;12(2):135-46.
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  5. Puntis JWL, Wilkins KM, Ball P. Hazards of parenteral treatment: do particles count? Arch Disease Childhood. 1992;67:1475-1477.
  6. Boehne M, Jack T, Kӧditz H, Seidemann K, Florian S, Abura M, Bertram H, et al. In-line filtration minimizes organ dysfunction: New aspects from a prospective, randomized, controlled trial. BMC Pediatrics. 2013:13(21):1-8.
  7. Kirkpatrick CJ, Rangoonwala R, Reshetnykov M, Barbeck M, Ghanaati S. Non-Equivalence of Antibiotic Generic Drugs and Risk for Intensive Care Patients. Pharmaceut Reg Affairs. 2013;2(1):1-7.
  8. Schäfer SC, Bison PA, Rangoonwala R, Kirkpatrick CJ. 0.2 µm in-line filters prevent capillary obstruction by particulate contaminants of generic antibiotic preparations in postischemic muscle. Chemother J. 2008;17:172-178.
  9. Lehr HA, Brunner J, Rangoonwala R, Kirkpatrick CJ. Particulate Matter Contamination of Intravenous Antibiotics Aggravates Loss of Functional Capillary Density in Postischemic Striated Muscle. Am J Respir Crit Care Med. 2002;165:514-520.
  10. Jack T, Boehne M, Brent BE, Hoy L, Kӧditz H, Wessel A, et al. In-line filtration reduces severe complications and length of stay on pediatric intensive care unit: a prospective, randomized, controlled trial. Intensive Care Med. 2012;38:1008-1016.
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  13. Chisholm CF, Behnke W, Pokhilchuk Y, Frazer-Abel AA, Randolph TW. Subvisible Particles in IVIg Formulations Activate Complement in Human Serum. J Pharm Sci. 2020;109(1):558-565. doi:10.1016/j.xphs.2019.10.041. 
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210420_Schiller_new CI_15_03_2021-7

使用静脉输液过滤器的益处

在过去 10 年中,多项人体临床研究表明,静脉输液在线过滤器对 ICU 患者具有积极影响。获益包括:保留器官功能,降低全身性炎症反应综合征 (SIRS) 的发生率,以及降低手术患者手术后静脉炎的发生率。