Prepacked ReadyToProcess™ columns with MabSelect™ VL protein L resin. The redesigned protein L ligand provides high binding capacity and improved alkaline stability. For affinity capture of antibody Fabs, bispecifics, and other variants containing a kappa light chain. MabSelect™ VL in ReadyToProcess™ columns is supplied made to order in 80 mm, 126 mm, 178 mm, 251 mm, 359 mm, and 450 mm column diameter sizes in different bed heights.
As the diversity of antibody variants increases, so does the need for chromatography resins that can capture and purify these variants. As an alternative to protein A, protein L resin can be used to capture antibody Fabs, bispecific antibodies, and other molecules containing kappa variants of the variable light (VL) chain. Protein L binds human kappa light chain subtypes 1, 3, and 4 and mouse kappa light chain subtype 1.
MabSelect™ VL resin showed a two-fold increase in binding capacity compared to our Capto™ L chromatography resin. This higher capacity provides productivity advantages in research and biomanufacturing.
MabSelect™ VL resin can withstand cleaning with 0.1 M NaOH, thanks to multimerization and modification of one of the domains of the native protein L ligand.
ReadyToProcess™ columns provide a robust design and validated column packing methods for consistent performance. Reduce cost by eliminating the need for column packing, preparation, and validation procedures.
ReadyToProcess™ columns fulfil industrial demands for security of supply, robust performance, and regulatory support.
MabSelect™ VL protein L resin is also available in 1 mL and 5 mL HiTrap™ prepacked columns for research applications and as bulk resins. Contact your Cytiva sales representative for more information.
